Step 1: Input Two miRNAs
Note:  This page accepts human miRNA genes (pre-miRNAs) as its input.
If the mature miRNA names (e.g. hsa-miR-140-5p) are provided, it will be collapsed into the corresponding miRNA gene (hsa-mir-140).
See sample example for details.
sample example

   

Step 2:(optional)
If you not choose Up/Down Regulation, prediction miRNA disease association does not consider the UP and Down Regulation information.
Considering up/down-regulation in the similarity calculation

Step 3: Predict
miRNA1 Result
miRNA2 Result
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If you use MISIM v2.0 in your work, please cite our publications:
Jianwei Li, Shan Zhang, Yanping Wan, Yingshu Zhao, Jiangcheng Shi, Yuan Zhou, and Qinghua Cui. MISIM v2.0: a web server for inferring microRNA functional similarity based on microRNA-disease associations. .
Wang D, Wang, J, Lu M, Song F, and Cui Q. Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases. Bioinformatics 2010 26: 1644-1650. doi:10.1093/bioinformatics/btq241